UC Santa Cruz runs the Data Coordination and Management program for the California Institute for Regenerative Medicine (CIRM) Center of Excellence in Stem Cell Genomics. The center brings together researchers at UCSC, Stanford University, the Salk Institute for Biological Studies, and several other research institutions.
The center applies genomics to stem cell research to gain a deeper understanding of the disease processes in cancer, diabetes, heart disease, and mental health. This understanding can ultimately lead to safer, more effective ways of using stem cells in medical research and therapy.
UC Santa Cruz is building a centralized database for genomic data produced and used by CIRM-funded stem cell researchers throughout the state. UCSC genomics experts Josh Stuart, David Haussler, and Jim Kent work closely with other investigators on center-initiated research projects. Led by Mike Snyder of Stanford, the center is expected to greatly enhance stem cell research in California and accelerate the development of new therapies.
The CIRM award includes independent and collaborative projects, including investigating disease mechanisms and the development of new technologies for this kind of work. The Data Coordination and Management program, directed by Stuart and co-directed by Haussler, will enable the research to be shared with other investigators around California and the world.
The Stem Cell Hub will provide a solution far more powerful than a simple data storage mechanism. While data archiving will be a major activity, the hub will also create a high-performance infrastructure to support both automated and semi-automated analyses of genomic data.
Stuart will also be working with Trey Ideker at UC San Diego to develop new "machine learning" tools specific for making discoveries in the anticipated stem cell datasets.